Acute-phase proteins and blood parameters as potential additional markers for ante-mortem tuberculosis diagnosis in European bison (Bison bonasus)

According to the International Union for Conservation of Nature, European bison (Bison bonasus) is a vulnerable species. susceptible mycobacterial infections, as evidenced by numerous confirmed tuberculosis cases in this Diagnostic methods have developed significantly recent years, but performing several parallel tests (serological, microbiological, molecular, cell-mediated based tests) still most appropriate algorithm confirm or exclude Mycobacterium complex infection This study primarily aimed determine whether some additional biomarkers could be helpful diagnosis bison. Whole blood and serum from eight with known TB status were used study. Four these caprae-positive four M. caprae-negative. The material was tested basic hematological biochemical parameters three selected acute phase proteins: ceruloplasmin, haptoglobin, amyloid A (SAA). found no significant changes tuberculosis, one advanced lesions showed increased concentrations haptoglobin SAA. These preliminary studies show that determining acute-phase proteins an supportive tool can diagnose its severity. Further research needed number individuals.